SM. Government Science college is situated at Shahrahe-e-Liaquat, Karachi.
Its three storey building is constructed in L-shape and is divided in three separate parts known as SARDAR HOUSE, KHAIRPUR HOUSE AND HASSAN ALI HOUSE. Adjacent to the Principal’s office on ground floor, there is a computer lab on the first floor with space for computer classes on the second floor.
Behind the Principal office, there is the auditorium of the college. But, unfortunately, this beautiful and only auditorium of the college has now been illegally and violently occupied by the vice chancellor of Sindh Madrasa-tul-Islam University, depriving the sm science college of this Auditorium where so many curricular activities had been held.